巜车里震动好爽H韩国电影|大地电影资源第二页|爱爱电影|国产电影一区二区三区|杨贵妃颤抖双乳呻吟求欢电影|电影免费在线观看

神經(jīng)性疼痛和炎癥 miScript miRNAs PCR

科技服務(wù) > PCR芯片實(shí)驗(yàn)服務(wù) > 神經(jīng)性疼痛和炎癥 miScript miRNAs PCR

神經(jīng)性疼痛和炎癥 miScript miRNAs PCR

神經(jīng)性疼痛和炎癥miScript miRNAs PCR Array Pain: Neuropathic & Inflammatory miScript miRNAs PCR Array
運(yùn)費(fèi) ￥0.00
（庫存 9999 件）
地區(qū)：上海
簡(jiǎn)介：Pain: Neuropathic & Inflammatory miScript miRNAs PCR Array
提供商：SAB
服務(wù)名稱：Pain: Neuropathic & Inflammatory miScript miRNAs PCR Array
Human Pain: Neuropathic & Inflammatory miScript miRNAs PCR Array: MIHS-120Z

The Human Pain miScript miRNA PCR Array profiles the expression of 84 miRNAs involved in the transduction, maintenance, and modulation of pain responses. Noxious environmental stimuli, tissue damage, and disease all evoke pain. Since it afflicts up to 20% of the population at any given time, pain provides both a massive therapeutic target and a route to understanding the molecular mechanisms of nervous system function. While neuropathic pain often results from damage to the peripheral (PNS) or central nervous system (CNS), peripheral tissue damage and/or inflammation generally initiates inflammatory pain. Neuropathic and inflammatory pain both cause activation of damage-sensing neurons (nociceptors) that innervate the skin, muscle and viscera and terminate in the laminae of the spinal cord dorsal horn. Transduction of pain signals requires the expression of specific proteins such as ion channels and neurotransmitter receptors. Because miRNAs should regulate genes encoding components of molecular pain pathways, researchers have hypothesized that they may be critically important master switches modulating pain. To better understand their importance and role in regulating nociception and pain circuitries, several miRNAs profiling experiments have demonstrated differential miRNA expression in rodent pain models such as contusive spinal cord injury, inflammatory muscle pain, and ischemia-reperfusion injury. The differential expression of miRNA in blood from patients with complex regional pain syndrome suggests that miRNA may also prove to be valuable biomarkers of pain. The differentially expressed miRNAs in these studied have also been shown and/or predicted to regulate genes involved in pain molecular mechanisms such as apoptosis and inflammation. This array analyzes the expression of miRNA found in be differentially expressed in typical models of pain. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green real-time PCR, the expression of a focused panel of pain-related miRNAs can be easily and reliably analyzed with this miScript miRNA PCR Array.
96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.



Upregulated by Pain:
Upregulated by Contusive Spinal Cord Injury: miR-1, miR-145-5p, miR-146a-5p, miR-146b-5p, miR-152-3p, miR-15b-5p, miR-17-5p, miR-199a-3p, miR-203a, miR-206, miR-20a-5p, miR-20b-5p, miR-214-3p, miR-21-5p, miR-223-3p, miR-30a-3p, miR-31-5p, miR-374b-5p, miR-378a-3p, miR-92a-3p, miR-92b-3p, miR-98-5p.
Upregulated by Ischemia-Reperfusion Injury: miR-132-5p, miR-133a-3p, miR-204-3p, miR-323a-3p, miR-365b-3p, miR-369-5p, miR-376b-5p, miR-505-5p, miR-665.
Downregulated by Pain:
Downregulated by Contusive Spinal Cord Injury: miR-129-2-3p, miR-137, miR-138-5p, miR-219a-2-3p, miR-219a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-323a-3p, miR-338-5p, miR-34a-5p, miR-379-3p, miR-495-3p, miR-543.
Downregulated by Inflammatory Pain: miR-10a-5p, miR-124-3p, miR-134-5p, miR-183-5p, miR-29a-3p, miR-98-5p, miR-99a-5p.
Downregulated by Ischemia-Reperfusion Injury: miR-146a-5p, miR-199a-3p, miR-210-3p.
Regulated by Pain:
Regulated by Contusive Spinal Cord Injury: miR-100-5p, miR-103a-3p, miR-107, miR-124-3p, miR-127-3p, miR-128-3p, miR-133a-3p, miR-133b, miR-154-5p, miR-181a-5p, miR-451a, miR-487b-3p, miR-99a-5p.
Complex Regional Pain Syndrome: miR-106b-5p, miR-126-3p, miR-130b-3p, miR-132-3p, miR-142-5p, miR-155-5p, miR-16-5p, miR-181a-5p, miR-20a-5p, miR-20b-5p, miR-221-3p, miR-25-3p, miR-93-5p.
Responsive to Antiinflammatories: miR-142-3p, miR-146b-5p, miR-203a, miR-208a-3p, miR-21-5p, miR-219a-2-3p, miR-219a-5p, miR-302d-3p.
Responsive to Neuroprotection: miR-199a-3p, miR-210-3p, miR-219a-2-3p, miR-323a-3p, miR-324-5p, miR-331-5p, miR-365b-3p, miR-369-5p, miR-376b-5p, miR-7-5p.
Apoptosis: miR-1, miR-106b-5p, miR-125b-5p, miR-128-3p, miR-133a-3p, miR-133b, miR-134-5p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-183-5p, miR-199a-3p, miR-203a, miR-206, miR-20a-5p, miR-210-3p, miR-214-3p, miR-21-5p, miR-221-3p, miR-25-3p, miR-29a-3p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-31-5p, miR-323a-3p, miR-34a-5p, miR-34c-5p, miR-365b-3p, miR-378a-3p, miR-451a, miR-7-5p, miR-92a-3p, miR-98-5p.
Inflammation: miR-106b-5p, miR-125b-5p, miR-127-3p, miR-128-3p, miR-130b-3p, miR-145-5p, miR-146a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-199a-3p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-210-3p, miR-23b-3p, miR-29a-3p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-323a-3p, miR-34a-5p, miR-34c-5p, miR-365b-3p, miR-543, miR-93-5p, miR-98-5p, miR-99a-5p.
Associated with Neuropathic Pain in Specific Cells:
Amygdala: miR-182-5p, miR-34c-5p.
Dorsal Root Ganglia Nociceptor: miR-103a-3p, miR-133a-3p, miR-134-5p, miR-143-3p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-7-5p.
Hippocampus: miR-125b-5p, miR-132-5p.
Immune Cells: miR-124-3p, miR-132-5p.
Insular Cortex: miR-133b.
Prefrontal Cortex: miR-181a-5p, miR-223-3p.
Spinal Dorsal Horn: miR-103a-3p, miR-124-3p, miR-134-5p, miR-23b-3p.
Other miRNA Involved in Pain: miR-339-5p, miR-96-5p


姓名
電話號(hào)碼
電子郵箱
公司名稱
地址
留言*
 
驗(yàn)證碼
提交
兰州市| 科技| 社旗县| 建始县| 哈尔滨市| 南和县| 阆中市| 博野县| 分宜县| 临高县| 文化| 桓仁| 克什克腾旗| 宣威市| 丽江市| 教育| 滦南县| 沙河市| 大洼县| 胶州市| 克山县| 平果县| 莱西市| 临澧县| 茌平县| 乌兰察布市| 称多县| 垫江县| 连城县| 环江| 乐山市| 乌鲁木齐县| 武山县| 花莲县| 三亚市| 札达县| 高尔夫| 旬阳县| 泽普县| 夏河县| 德钦县|